Skip to main content

MUC5B-dominated mucus accumulation in chronic phase COVID-19 alveolar spaces, courtesy of Takanori Asakura, M.D., Ph.D.


The Chen lab at the Marsico Lung Institute is committed to studying muco-obstructive pulmonary diseases using state-of-the-art technology in a variety of animal models as well as primary human tissues and cells. We are dedicated to performing translational research and to developing therapeutic options that aim to help adults and children with chronic pulmonary diseases worldwide.


Research interests:

  • Stem cells in the lung
  • Epithelial ER stress and idiopathic pulmonary fibrosis (IPF)
  • Pulmonary disorder in Job’s syndrome
  • IL1β-mediated inflammation in cystic fibrosis lung
  • STAT3-regulated mucociliary clearance
  • In vitro lung cell culture models